Seasonal affective disorder is a disorder where there are difficulties where there are alterations in received sunlight. Seasonal affective disorder is more noticeable in winter months where there are more alterations from received sunlight to no received sunlight. In seasonal affective disorder moods become very bleak in seconds when clouds suddenly block the sun. Moods in seasonal affective disorder become less bleak where buildings are entered where alterations in received sunlight stop for some hours.
Seasonal affective disorder is due to dysregulations in calcium homeostasis. Supplements that enhance calcium homeostasis can treat seasonal affective disorder. Vitamin K2 MK-7, vitamin D3 and vitamin A assist can assist with calcium homeostasis.
100-200 micrograms of vitamin K2 MK-7 from Bronson Laboratories is supplemented 3-6 times a day away from dinners in treatments of seasonal affective disorder. Vitamin K2 MK-7 that is derived from natto should not ever be taken.
Vitamin K2 MK-7 capsules are supplemented. Dry vitamin K2-MK-7 is lots more effective than vitamin K2 MK-7 in softgels.
 Vitamin K2 MK-7 is supplemented only on basically empty stomachs Supplementing vitamin K2 MK-7 3- 6 times a day assists with calcium homeostasis. Vitamin K2 MK-7 has low toxicity. Vitamin K2 Mk-7 has to be taken in divided dosages throughout the day. Calcium ions are bound by GLA domain proteins. GLA domain proteins require vitamin K to bind calcium. Vitamin K2 MK-7 has a half-life of approximately 3 days which makes vitamin K MK-7 a preferred supplemental formulation of vitamin K.
Vitamin D3, vitamin A and vitamin K2 MK-7 initially have to be available in gastrointestinal tracts. Dry formulations of vitamin D3, vitamin A and vitamin K2 MK-7 are supplemented.
A multivitamin pills should contain only around RDA amounts of vitamins and should not ever contain chelated minerals. Multivitamin pills should not contain plant extracts.
A sole 21st Century Essential multivitamin containing vitamin D3 and vitamin A and no biotin is supplemented 3 times a day where dinners are eaten. Finding appropriate multivitamin supplements presents difficulties.
High amounts of vitamin A are of less than zip assistance. Dosages of 10,000 IUs of vitamin AÂ are safe in regards to birth defects. However, dosages of vitamin A that are less than dosages associated with birth defects can be depressing. Individuals still need to supplement with vitamin A though.
Caffeine can result in release of intracellular calcium by making ryanodine more sensitive. Affects of caffeine on calcium are ameliorated by vitamin D3, vitamin A and vitamin K2 MK-7. See this post on drinking coffee.
Supplements with fat-soluble nutrients have to be refrigerated. Supplements with vitamin D3, vitamin A and/or vitamin K2 MK-7 have to be refrigerated.
 Aldehyde oxidase is a molybdenum containing protein. Aldehyde oxidase is required for metabolism of vitamin A to 9-cis retinoic acid and all-trans retinoic acid (ATRA). Aldehyde oxidase contributes to ATRA synthesis in human livers.
There has been a huge amount of research on vitamin D. Vitamin D receptors form heterodimers with retinoid-X-receptors (RXRs).
The natural ligand of RXR's is 9-cis retinoic acid. With low levels of 9-cis retinoic acid vitamin D receptors do not work.
Low levels of aldehyde oxidase result in low levels of 9-cis retinoic acid resulting in dysregulation of vitamin D regulated genes. There are difficulties with vitamin D regulated processes where part of the difficulties are due to low formation of 9-cis retinoic acid due to low levels of aldehyde oxidase.
Legumes are symbiotic with nitrogenase containing organisms. Nitrogenase is a molybdenum containing protein but, oxidation states of molybdenum in nitrogenase are not oxidation states of human molybdenum-dependent proteins. Legumes, for example, beans and soy, contain high levels of molybdenum. Peanuts are legumes too.
Molybdenum from legumes by not being in correct oxidation states for human molybdenum proteins could adversely affect human molybdenum-containing proteins. In treatment of seasonal affective disorders eating legumes, for example, beans. peanuts and/or soy have to be avoided. Soy is in lots of food items, for example condiments and salad dressings. Ingredients labels of foods have to be checked and foods with soy not eaten.
Molybdenum glycinate should not ever be supplemented and I underline ever. Molybdenum from sodium molybdate should not be supplemented either. Xanthine oxidase is a molybdenum containing protein that interacts with iron. Xanthine oxidase levels increase in gastrointestinal tracts where there is supplementation with sodium molybdate.
To treat illnesses connected to dysregulations of calcium homeostases dietary antioxidants have to be avoided. Foods with spices have to be avoided and antioxidant-laden drinks, particularly sodas and/or sports drinks have to be avoided. Foods with natural and/or artificial flavors have to be avoided. Supplements containing antioxidants should not be taken , however, appropriately formulated multivitamin pills containing around RDA amounts of antioxidant vitamins are supplemented at dinners.
Amongst myriad adverse effects of dietary antioxidants dietary antioxidants could also adversely affect aldedyde oxidase. Aldehyde oxidase requires O2.
Treatment of seasonal affective disorders is not a minor course correction. Seasonal affective disorders are major mental illnesses that can result in desolations.
Individuals treated for seasonal affective disorder could still have depressions, chronic fatigue syndrome/long haul COVID-19 and/or difficulties with dietary antioxidants. To treat depressions see this post. To treat chronic fatigue syndrome/long-haul COVID-19 see this post. To re-regulate systematic oxidant defenses and address high levels of antioxidants in diets see this post.