L-citrulline and protein synthesis

Taking supplements listed below results in epigenetic alterations Getting off supplements listed below could be very difficult even almost impossible.

L-citrulline and increased protein synthesis

L-citrulline can increase muscle protein synthesis. Leucine is a branched-chain acid that is required for protein synthesis in muscles. For L-citrulline to work as a supplement branched-chain amino acids have to also be supplemented. 

Carbamoyl-phosphate synthase synthesizes carbamoyl phosphate. Carbamoyl phosphate is a substrate for ornithine carbamoyltransferase which synthesizes L_citruliine.

Carbamoyl-phosphate synthase 1 is exclusively expressed in gastrointestinal tracts and livers. Ornithine carbamoyltransferase is also exclusively expressed in gastrointestinal tracts and livers. The upshot is that L-citrulline is exclusively synthesized in gastrointestinal tracts and livers.

Carbamoyl-phosphate synthase has bicarbonate as a substrate. Carbonated drinks initially increase activities of carbamoyl phosphate synthetase which results in coutervailing steps which result in hypermeythylations of genetic loci closely connected to carbamoyl phosphate synthetase which decreases levels of carbamoyl phosphate synthetase decreasing levels of nitric oxide. Synthesis of L-citrulline subsequent to a time is decreased by sodas, seltzers, beer and other carbonated drinks which have pronounced effects on bicarbonate in gastrointestinal tracts. 

Around 2 grams of L-citrulline could be supplemented three times a day where dinners are eaten where branched-chain amino acids are also supplemented. L-citrulline marketed by Bulksupplements is supplemented.

Where L-citrulline is supplemented branched-chain amino acids have to be supplemented. Leucine  increases protein synthesis.

Leucine is a branched chain amino acid. Where leucine is supplemented valine and isoleucine also have to be supplemented otherwise there could be amino acid imbalances.

Around 3 grams of a 2:1:1 (leucine, valine, isoleucine) formulation of branched-chain amino acids is supplemented three times a day where dinners are eaten. A 2:1:1 formulation of branched-chain amino acids marketed by Bulksupplements is supplemented.

Due to shortages in L-citrulline there could be shortages in L-arginine which is synthesized from L-citrulline leading to shortages in L-creatine. L-creatine is synthesized from L-arginine and glycine

L-creatine marketed by Bulksupplements would also be supplemented. Around 4 grams of creatine is supplemented three times a day where dinners are eaten. As bags of Bulksupplements do not reseal contents have to be transferred to containers that have lids and/or opened bags have to be taped shut.