Activities of enzymes can be increased by vitamins and/or trace minerals

Activities of enzymes can be increased by taking vitamins and/or trace minerals but that can lead to huge difficulties. Genetic loci in gastrointestinal tracts and/or livers closely associated with such enzymes can become hypermethylated as countervailing steps turning off transcriptions of genes. Various vitamin and mineral supplements can stop being effective subsequent to such genetic loci being hypermethylated.

Example of genetic loci in gastrointestinal tracts and/or livers that can become hypermethylated due to taking vitamins and/or trace minerals are genetic loci closely associated with deiodinases due to supplementation with selenium. genetic loci closely associated with pyridoxal oxidases and pyridoxal kinases due to supplementation with pyridoxine, genetic loci closely associated with sodium dependent multivitamin transporters due to supplementation with biotin.

Genetic loci in gastrointestinal tracts closely associated with carbamoyl phosphate synthetase can become hypermethylated due to drinking carbonated drinks. Bicarbonate is a substrate for carbamoyl phosphate synthetase. Carbamoyl phosphate synthetase is needed to synthesize L-arginine.